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Renin Angiotensin Aldosterone System
Here is a quick and simple review of Renin Angiotensin Aldosterone System (RAAS).
Renin Angiotensin Aldosterone System, is one of the ways that our body uses to maintain Blood Pressure. It is important to understand that this a chronic way in controlling blood pressure. The reason being there are Enzymes and Hormones required in this system which take some time to get synthesized.
The "ACUTE" way of compensating Low Blood Pressure, is through ANS system which releases Neurotransmitters such as Norepinephrine (NE). In turn NE acts on "α1" receptors located on Blood vessels and causes vasoconstrictions which results in Increase Blood pressure. It also Activates "Beta1" receptors on the heart and as the results Cardiac Output increases which supplies more blood to the tissues.
Aldosterone is a hormone that is produced by Adrenal glads (zona glomerulosa) which acts on the Distal tubules and collecting ducts of the nephrons resulting in Sodium reabsorption into the circulation and Potassium and Hydrogen Ions secretion into the tubules to be excreted out with urine.
What is important here is that, water always follows Sodium, therefor when Aldosterone causes Sodium reabsorption it will also lead to Water reabsorption as well which will eventually lead to increase in Blood Pressure.
Please watch and if you have any questions you can always ask me in the comment section and i will be more than happy to provide you a good explanation.
Therefor this system becomes very important in treating hypertensive patients due to many pharmacological drugs we now have available to us today which will inhibit key enzymes in the Renin Angiotensin Aldosterone System (RAAS), that will ultimately result in inhibition of Aldosterone synthesis. This will lead to inhibit of Sodium and Water reabsorption which will ultimately result in fluid loss and decrease in blood pressure.
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